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RBM3 overexpression ameliorates renal function and histopathological damage in rats at 48 h after burns. (A) HE staining of renal tissue. Scale bar = 100 μm, 50 μm. (B) Immunofluorescence detection of kidney injury molecule <t>KIM‐1.</t> Scale bar = 100 μm. (C) Quantitative results shows the decreased KIM‐1 expression by RBM3 OE. (D) Renal function test results suggests the reduced CREA level by RBM3 OE. (E) Renal function test results suggests the decreased UREA level by RBM3 OE. (* p < 0.05 vs. Control, # p < 0.05 vs. AKI, & indicates p < 0.05 vs. AKI + RBM3 NC).
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RBM3 overexpression ameliorates renal function and histopathological damage in rats at 48 h after burns. (A) HE staining of renal tissue. Scale bar = 100 μm, 50 μm. (B) Immunofluorescence detection of kidney injury molecule <t>KIM‐1.</t> Scale bar = 100 μm. (C) Quantitative results shows the decreased KIM‐1 expression by RBM3 OE. (D) Renal function test results suggests the reduced CREA level by RBM3 OE. (E) Renal function test results suggests the decreased UREA level by RBM3 OE. (* p < 0.05 vs. Control, # p < 0.05 vs. AKI, & indicates p < 0.05 vs. AKI + RBM3 NC).
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RBM3 overexpression ameliorates renal function and histopathological damage in rats at 48 h after burns. (A) HE staining of renal tissue. Scale bar = 100 μm, 50 μm. (B) Immunofluorescence detection of kidney injury molecule KIM‐1. Scale bar = 100 μm. (C) Quantitative results shows the decreased KIM‐1 expression by RBM3 OE. (D) Renal function test results suggests the reduced CREA level by RBM3 OE. (E) Renal function test results suggests the decreased UREA level by RBM3 OE. (* p < 0.05 vs. Control, # p < 0.05 vs. AKI, & indicates p < 0.05 vs. AKI + RBM3 NC).

Journal: The FASEB Journal

Article Title: Augmenting the Endogenous RBM3 Response Protects Against Burn‐Induced Acute Kidney Injury by Enhancing Macrophage‐Mediated Resolution of Inflammation

doi: 10.1096/fj.202503604RR

Figure Lengend Snippet: RBM3 overexpression ameliorates renal function and histopathological damage in rats at 48 h after burns. (A) HE staining of renal tissue. Scale bar = 100 μm, 50 μm. (B) Immunofluorescence detection of kidney injury molecule KIM‐1. Scale bar = 100 μm. (C) Quantitative results shows the decreased KIM‐1 expression by RBM3 OE. (D) Renal function test results suggests the reduced CREA level by RBM3 OE. (E) Renal function test results suggests the decreased UREA level by RBM3 OE. (* p < 0.05 vs. Control, # p < 0.05 vs. AKI, & indicates p < 0.05 vs. AKI + RBM3 NC).

Article Snippet: The sections were then incubated overnight at 4°C with primary antibodies against KIM‐1 (Proteintech, 30948‐1‐AP, 1:200), CD86 (Bioss, bs‐43589R, 1:200), CD206 (Affinity, DF4149, 1:200), F4/80 (1:200), and Caspase‐3 (1:200).

Techniques: Over Expression, Staining, Immunofluorescence, Expressing, Control